Secret level:
Go to the ATM in the first level where you can play as Venom. Press B + Y to jump to a secret level.

Skip fighting scenes:
Tap B, C repeatedly when the Comic Book scene with Carnage and the captured Venom appears. The scenes of Spider-Man fighting will be skipped.

Hint: Fighting more than one Boss:
When fighting more than one boss, do not hit them. Instead, wait until you are in between them (or you can climb a wall before they appear). When you are between them, use your web and if they both are caught, they will both die.

Hint: Easy kills:
When you know that some enemies are coming up, kill in smaller groups than they are ready to appear in. Sometimes only some enemies will appear when you reach a certain point or there can only be a limited number of enemies on the screen at once.

Hint: Instant Boss kills:
You can kill some Bosses instantly at the end of each level if you do the following. Do not hit them, but go onto a wall. When they have stopped and are on opposite sides of each other, go down and try to do a "Double Smash" on them. If successful, you will automatically kill them and will also get an extra life.

Hint: Easy Boss battles:
Using Cloak against Bosses works the best. When using him, make sure you are away from the enemies you are fighting. They still can move when he appears, but for only a few seconds. Use the Superhero icons wisely and only in emergencies. You never know when you will need them.

Hint: The Alleyway: Items:
In the Alleyway level, you can climb the wall on the screen before the church doors, then swing over at the top for an extra life and two hearts. At the end of the level, climb the rightmost wall for another continue.

Hint: The Climb: Secret room:
Go to the far right window in the bottom row of windows. Climb the wall, get over the window, and drop down. This will take you to a secret room.

Hint: The Deep: Extra life:
When you start in the Deep level, go right and to find an extra life.

Hint: New York Street 1: Extra Life:
On level 1, New York Street 1, wait until you are at the end of the level at the screen with the Boss. Before the hair sisters attack, jump onto the wall. There is an extra life behind where your health bar is located.

Hint: The Rooftop 1: Extra life:
On the first Rooftop level, hit the water tower about ten to fifteen times. It will break, revealing an extra life where the tower was located. Note: If you throw the tower at Doppelganger, it will end the battle immediately.

Hint: The Rooftop 2: Superhero icons:
In the Rooftop 2 level, jump into the tree for some Spidey icons. Be sure not to fall.

Hint: Ruined Boys Home: Secret room:
Get hit by Carnage in front of the door. You will find a room filled with great things.