Hint: Easy money:
Set the value of all your players on the left half of the squad screen as £99.999 million, and five of those on the right as the same. Then, set the sixth as about £45 to 50 million and go to "Finances". You should be able to take out a loan at about negative £640 million. Do this and immediately repay the loan. You should end up with about £95 million to spend. This can be repeated as often as desired, but very rarely your money will reset to zero and you will have to do it again.

Hint: Player placement:
The game has a problem with full-backs and central midfielders -- it makes them play awful. To get round this, play your full-backs further wide than they start, cancel their passes to the wingers, and give them forward runs and early crossing instructions. Play a 4-5-1 formation with one central midfielder just in front of the back 4, and two just behind the striker (level with the wingers). Play one with high vision (70+) on the left and one with high shooting (80+) on the right.